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Orthomolecular Medicine News Service, March 10, 2023

Resolving Persistent Spike Protein Syndrome

by Thomas E. Levy, MD, JD

OMNS (March 10, 2023) Editor's Note: Dr. Levy's paper, to follow, is both interesting and important. One might think it is not orthomolecular as such and is not really appropriate for the Orthomolecular Medicine News Service. While I respect that viewpoint, I do not agree. My publication mentor, Dr. Abram Hoffer, taught me by example that physician viewpoints need to be presented for consideration. "Where are the good old days," he wrote, "when honest physicians honestly reported what they saw in language that any doctor could understand?" The NY TIMES used to live by the motto, "All the news that's fit to print." During the heyday of COVID hysteria we saw otherwise. There was considerable bias, even censorship, by legacy media. I do not intend to make that mistake. With nearly 20 years of continuous publication, as long as I am editor, OMNS will stand for open discussion of plausible medical ideas that can save lives. In conjunction, readers should work with their own healthcare providers before making any heath decision. That is common sense. Recognizing the value of a second - or even a third - medical opinion is also common sense. Abram taught me to be inclusive, not exclusive. OMNS will present these ideas. Linus Pauling, who gave orthomolecular medicine its name, said "The best way to have a good idea is to have a lot of ideas." Dr. Pauling, a chemist, was roundly criticized by the medical profession for speaking out on health and nutrition. I am glad he did. - Andrew W. Saul, OMNS Editor-in-Chief

As the acute cases of COVID have continued to decline, the prevalence of the Persistent Spike Protein (PSP) syndrome has continued to increase. The spike protein is that part of the COVID pathogen that attaches to ACE2 receptors throughout the body and permits the entry of the entire virus into the newly infected cell. There appear to be no cells, tissues, or organs in the body that are completely spared from this PSP attack once enough of it has been introduced into the body.

The persistent presence of the spike protein has been shown to be secondary to the inability to completely resolve a bout of COVID (chronic COVID or long-haul COVID) as well as the spike protein exposure from mRNA inoculation(s). And as more time has passed, the PSP syndrome following one or more mRNA shots has emerged as the most common reason for PSP, especially following a booster injection. Not surprisingly, the likelihood of developing a PSP syndrome relates directly to the total amount of spike protein exposure, and the amounts delivered by repeated inoculations substantially exceed the amounts that result from incompletely resolved cases of COVID.

The goal of any therapy designed to eliminate a chronic spike protein presence in the body needs to address its presence in the blood, its presence on the many ACE2 binding sites throughout the body, its presence inside the cells, and the mechanisms that allow it to replicate itself and keep it from being eliminated completely in the body. It has been shown that the sickest of PSP patients have intact spike protein circulating in the blood. [1]

However, eliminating it from the blood does not assure a cure. It is also vital to destroy the cells where the virus and/or spike protein replication is taking place, as well as to destroy any cells that are producing new spike protein because of the presence of the vaccine-supplied mRNA. It remains unclear at the time of this writing whether the cells of tissues or organs not known to regenerate on a regular basis will instead serve as virus/spike protein reservoirs that are not readily accessible to therapeutic agents. Multiple autopsy studies have revealed the presence of spike protein throughout the body, without any particular areas being spared. [2,3]

By itself, the spike protein is also toxic. As all toxins ultimately inflict damage by oxidizing biomolecules needed for normal metabolic function, any effective PSP protocol needs to include significant antioxidative capacity in order to repair damaged (oxidized) biomolecules. Spike protein has been shown to induce inflammation (acute oxidative stress) even without resulting in viral infection. [4]

Bio-Oxidative Therapies

While any therapy that can eradicate an infectious agent must involve its destruction via enhanced oxidation, the most prominent of these therapies involve the appropriate application of:

  • Vitamin C (multiple modalities)
  • Hydrogen peroxide (multiple modalities)
  • Ozone (multiple modalities)
  • Ultraviolet blood irradiation
  • Hyperbaric oxygen

While still not widely appreciated, these bio-oxidative therapies have been curing acute infectious diseases for very many years now. The resolution of acute viral infections has been especially well-established to result with any of these therapies administered individually or when combined together. All these therapies share the ability to rapidly increase the oxidative stress inside the pathogens themselves and/or the cells that have become infected with the pathogens. Nothing destroys a pathogen or pathogen-infected cell that cannot elevate such oxidative stress to lethal levels. And even though different treatments might have unshared mechanisms in fueling this increased oxidative stress, it is this singular effect that ultimately resolves the infection.

Vitamin C and Hydrogen Peroxide

Vitamin C (VC), interacting directly with extracellular and intracellular hydrogen peroxide (HP) already in the body, works to eradicate pathogens, including the COVID pathogen, by a mechanism known as the Fenton reaction. This reaction produces hydroxyl radical formation in a pathogen or a pathogen-infected cell, which works to oxidize whatever it is next to when it is formed. This ultimately results in the destruction of the pathogen, inside or outside of the cell, when enough VC and HP are present.

Enough HP by itself will also quickly oxidize pathogens and their infected host cells. This can occur with HP nebulization, the direct ingestion of appropriately-dosed HP, and the appropriate infusion of hydrogen peroxide intravenously. Intravenous HP has long been established as a powerful anti-viral agent, curing many of the most critically ill patients in the 1918 influenza pandemic. [5] HP nebulization is especially effective in clearing out areas of chronic pathogen colonization in the nose and throat areas. Even though such areas are usually asymptomatic, they work to keep these "virus-manufacturing" areas of the body much more susceptible to the contraction of new infectious agents, viral or otherwise.

An agent naturally present in the body in large amounts, hydrogen peroxide plays an important role in the pathogen-killing effect of all the bio-oxidative. While the biochemical details of these bio-oxidative therapies remain to be clearly defined, the anti-pathogen effect of HP appears to be an essential part of the final common pro-oxidant pathway in these therapies that is needed to kill the pathogen and clinically resolve the infection.

The nature of the immune system gives further support to the role of both VC and HP in the control and resolution of infections. The monocytes and phagocytes in the immune response are the first cells to appear at new sites of inflammation or infection. Of note, these two types of immune cells have exceptionally high levels of both VC and HP inside them. This results in the immediate delivery of the most important elements of the pathogen-killing Fenton reaction to the new site of infection. [6-10]


No agent exceeds the pro-oxidant, pathogen-killing ability of properly-administered ozone. Interestingly, the basic chemical structure of ozone is very close to HP. HP (H2O2) can be regarded as a dioxide of hydrogen, and ozone (O3) can be regarded as a dioxide of oxygen. This dioxide-like structure (two bound oxygens in the molecule) is also present in other molecules with powerful pro-oxidant, pathogen-killing capacity. Chlorine dioxide, nitrogen dioxide, sulfur dioxide, carbon dioxide, titanium dioxide, and silica dioxide have all been shown to have significant anti-pathogen properties. [11-17]

Like HP, ozone has been shown to increase blood oxygen levels and oxygen delivery to the tissues in addition to its anti-pathogen effects. Such an effect can only be expected to further enhance the healing of damaged tissues after the pathogen presence has been eradicated. Furthermore, tumor cells that have been incubated in an ozonated medium have been shown to accumulate HP, supporting the concept that ozone utilizes HP-related mechanisms in its pro-oxidant response involved in cancer cells as well as pathogens. [18] Anything that can increase HP levels in or around a target cell or pathogen greatly facilitates its susceptibility to destruction when the microenvironment triggers the conversion of HP to hydroxyl radical.

Although VC appears to have been much more studied during the pandemic as an anti-COVID agent, there is no evidence to suggest that ozone is not just as effective in destroying the COVID pathogen versus any other pathogen. [19] Furthermore, ozone has been shown to be clearly beneficial while maintaining a high safety profile when used as adjuvant therapy in the treatment of advanced COVID patients. [20-23] Applied early enough in the course of a COVID infection, ozone significantly reduces hospitalization time and improves blood oxygenation. Laboratory markers of coagulation and inflammation are significantly improved with such therapy as well. [24,25]

The PSP (persistent spike protein) syndrome is now affecting literally millions of patients around the world. Some are due to the PSP presence resulting from COVID infection that never really resolves completely. However, many more now appear to be resulting from the COVID shots. Not surprisingly, the likelihood of having PSP syndrome directly correlates to the total amount of spike protein in the body, and every shot supplies more of this toxic protein. Feeling well after the first one or two shots and then deteriorating rapidly following a booster shot is an increasingly common occurrence.

Chronic COVID symptomatology secondary to the PSP syndrome responds very well to oxygen-ozone autohemotherapy. Fatigue remains the singular most common symptom in such PSP patients, even though very many other symptoms can be present as well. In fact, over 50 long-term symptoms from COVID have been reported. [26] In a series of 100 chronic COVID patients suffering prominently with chronic fatigue, one to nine autohemotherapy ozone treatments were administered over a period of up to three weeks. All the patients reported less fatigue, and impaired functionality secondary to chronic fatigue was restored to a normal level in at least two thirds of the patients. [27]

Anecdotal evidence seen with before-and-after dark field examinations on patients with indirect evidence of ongoing spike protein evidence (increased rouleaux formation) show very clearly that ozone treatments quickly resolve this PSP-associated abnormality seen under the microscope. [28]

Since PSP appears to be the primary, or even sole, culprit in patients suffering from chronic COVID symptomatology, the ability of ozone to resolve such symptomatology indicates that any spike protein present in the body can be obliterated by properly-administered ozone. Since ozone is known to degrade and inactivate intact viruses, it is perfectly logical that it can degrade "pieces" of a virus, such as the spike protein part of the COVID pathogen.

Ultraviolet Blood Irradiation

Direct ultraviolet (UV) irradiation without involving blood irradiation has been well-established for a very long time to be an ideal way to kill pathogens outside of the body. [29-31] The COVID pathogen has also been shown to be easily inactivated by such irradiation. [32]

The awareness of the impact of direct UV irradiation on pathogens eventually lead to investigating the impact of ultraviolet blood irradiation (UBI) on patients with various infections. UBI proved to be as effective against pathogens inside the body as it was against pathogens outside the body. In a series of 47 early to moderate advanced cases of spinal type polio infection, UBI alone cured all of the cases. Dramatic responses have also been documented for the UBI treatment of acute viral hepatitis and advanced sepsis. Even conditions such as arthritis and asthma have responded well to UBI. [33,34]

UBI has also been shown to increase the content of HP inside the phagocytic white blood cells. This fits well with the concept that all the bio-oxidative therapies ultimately utilize the anti-pathogen properties of HP to resolve an infection. [35]

Hyperbaric Oxygen Therapy

An exceptionally powerful therapy for resolving deep-seated and otherwise non-healing infections, hyperbaric oxygen therapy (HBOT) involves the inhalation of oxygen inside a chamber that is pressurized to between 1.5 to 3.0 times normal atmospheric pressure. In addition to increasing blood and tissue oxygen levels, HBOT also appears to utilize the anti-pathogen properties of HP in killing pathogens and resolving infections. [36]

The expense and limited availability of HBOT around the country is the main limiting factor in its more routine usage. It is always worth remembering that this therapy exists when dealing with life- and limb-threatening infections. No patient should ever have an infected limb amputated before all the bio-oxidative therapies, including HBOT, have been administered.

Persistent Spike Protein Treatment

PSP syndrome following unresolved COVID infection and/or following one or more COVID inoculations is gradually becoming its own pandemic. The massive morbidity and mortality secondary to this syndrome must be vigorously treated whenever encountered, as it does not appear to be a condition that many people can resolve on their own, even over an extended period of time.

Except for the rarest of individuals, one or more bio-oxidative therapies must be included in an optimal treatment protocol. Vitamin C, hydrogen peroxide, ozone, and ultraviolet blood irradiation would be the best initial approaches. If a protocol utilizing the highest doses of vitamin C does not readily resolve the persistent symptoms seen in the PSP syndrome, there should be no hesitation to seek out a qualified healthcare practitioner familiar with the proper administration of ozone. In addition to the resolution of all persistent and chronic symptoms associated with the PSP syndrome, troponin and D-dimer should end up normal, and the most common of inflammation-related blood tests, like CRP, should be at minimal levels inside the laboratory reference range.

A good protocol, only administered with the oversight of a qualified healthcare practitioner, for the PSP syndrome should include:

  • Ozone autohemotherapy, followed by
  • IV vitamin C (50 to 150 grams daily); or any oral form in the highest doses possible
  • IV or oral hydrocortisone (25 to 50 mg) in the IV or with the first oral dose of vitamin C
  • Ultraviolet blood irradiation if available
  • Hydrogen peroxide nebulization
  • Methylene blue, 25 to 50 mg two or three times daily

It is up to the treating practitioner to determine how long the protocol should be administered and/or modified as the patient responds positively.

Proteolytic enzymes that can break down the spike protein should also be added (bromelain, N-acetyl cysteine, nattokinase).

A protocol like this can be used for many conditions, but this one is designed in particular to resolve the PSP syndrome.

(OMNS Contributing Editor Dr. Thomas E. Levy is board certified in internal medicine and cardiology. He is also an attorney, admitted to the bar in Colorado and in the District of Columbia. The views presented in this article are the author's and not necessarily those of all members of the Orthomolecular Medicine News Service Editorial Review Board.)


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Ron Hunninghake, M.D. (USA)
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Andrew W. Saul, Ph.D. (USA), Editor-In-Chief
Associate Editor: Robert G. Smith, Ph.D. (USA)
Editor, Japanese Edition: Atsuo Yanagisawa, M.D., Ph.D. (Japan)
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