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Bone Health and Osteoporosis: An Orthomolecular PerspectiveEditorial by Richard Z. Cheng, MD, PhD and Thomas E. Levy, MD, JDOMNS (Aug. 16, 2022) Osteoporosis, like most other disease, is caused by many factors including deficiencies of essential nutrients such as vitamin D. But the central dogma has been promoting just prescription drugs and calcium supplements. This strategy sounds simple and straightforward, but unfortunately not only does it not work, it may even be harmful. There is a rich body of data in the literature showing that lifestyle, nutrition, toxins, and hormonal balance have an impact on bone health and osteoporosis. A brief summary of this research is presented here. For optimal results, the practical management of osteoporosis and other chronic diseases should incorporate this knowledge. A recent issue of New England Journal of Medicine published an article claiming that vitamin D supplementation does not improve osteoporosis. [1] Forbes magazine immediately jumped the gun: Stop Taking Vitamin D Already! [2] Vitamin D is more than just a vitamin; it is more like a hormone with pleiotropic effects on the body, including immune-boosting effects that fight against Covid-19. Giving advice to stop taking vitamin D based on just one negative study is not only unscientific, it's against common sense. (We will not discuss the study design issues, as Dr. William Grant will presently offer his critique of NEJM article's poor study design). Because vitamin D is involved in many aspects of health, maintaining an adequate level is critically important. Yet many individuals are deficient, which has likely increased the rates of infection and death from Covid-19. There have been many clinical studies on vitamin D3 and Covid-19 in the last two years, including a special collection of Micronutrients for Viral Infections - Reference Bibliography by International Society for Orthomolecular Medicine, [3] and several such papers on Orthomolecular Medicine News Service including a recent review by Dr. Grant. [4] Have the author and editor of the Forbes article not been updated on the vitamin D research -- or is there something else? Prescription drugs and calcium supplements have no significant benefits for treating osteoporosis. Earlier this year, a meta-analysis published on JAMA found that bisphosphonates, a major class of prescription osteoporosis drugs offer very few benefits to osteoporotic patients. [5] Another meta-analysis on JAMA showed calcium supplements do not offer significant help to osteoporosis. [6] Calcium supplements increase the risk of cardiovascular diseases and cancer. To make matters worse, calcium supplements not only do not improve your health, but may actually increase your risks of cardiovascular diseases and cancer, as reported on a recent study. [7] Many studies in the literature have demonstrated the risks of calcium supplements, as summarized by Thomas Levy. [8,9] Prescription drugs and calcium supplements are not helpful and may even be harmful. So, are osteoporosis patients doomed? Not at all. There is a rich body of evidence in the medical literature showing that osteoporosis is a multifactorial disease -- and that a healthy lifestyle, reversing a toxin overload (by detoxification), optimal nutrition, and hormonal balance are effective in improving not only osteoporosis but overall health. [8] Highlights of some of the relevant research:
To put these altogether, we recommend an integrated management of osteoporosis that includes at least the following:
References:1. LeBoff M, Chou SH, Ratliff KA, et al. (2022) Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults. NEJM https://pubmed.ncbi.nlm.nih.gov/35939577 2. Salzberg S (2022) Stop Taking Vitamin D Already! Forbes https://www.forbes.com/sites/stevensalzberg/2022/08/01/stop-taking-vitamin-d-already 3. Micronutrients for Viral Infections - Reference Bibliography. ISOM https://isom.ca/micronutrients-viral-infections 4. Grant WB. (2021) Vitamin D's Role in Reducing Risk of SARS-CoV-2 and COVID-19 Incidence, Severity, and Death. Nutrients 14:183. https://pubmed.ncbi.nlm.nih.gov/35011058 5. Deardorff WJ, Cenzer I, Nguyen B, Lee SJ (2022) Time to Benefit of Bisphosphonate Therapy for the Prevention of Fractures Among Postmenopausal Women With Osteoporosis: A Meta-analysis of Randomized Clinical Trials. JAMA Intern Med. 182:33-41. https://pubmed.ncbi.nlm.nih.gov/34807231 6. Zhao J-G, Zeng X-T, Wang J Liu L (2017) Association Between Calcium or Vitamin D Supplementation and Fracture Incidence in Community-Dwelling Older Adults: A Systematic Review and Meta-analysis. JAMA 318:2466-2482. https://pubmed.ncbi.nlm.nih.gov/29279934 7. Park, J-M, et al. (2022) Calcium Supplementation, Risk of Cardiovascular Diseases, and Mortality: A Real-World Study of the Korean National Health Insurance Service Data. Nutrients 14:2538. https://pubmed.ncbi.nlm.nih.gov/35745268 8. Levy T. (2013) Death By Calcium. MedFox Pub. ISBN-13: 978-0615889603 https://www.medfoxpub.com/medicalnews/product/S-DBC/Death-by-Calcium/Death-by-Calcium 9. Levy T, 成长. 隐形杀手---补钙剂(中文版): 补钙无助于骨质疏松, 反而促进血管硬化, 心脏病(中文版)。 (Kindle Publisher, 2017). 10. Nakamura K, Saito T, Kobayashi R, et al. (2011) C-reactive protein predicts incident fracture in community-dwelling elderly Japanese women: the Muramatsu study. Osteoporos Int. 22:2145-2150. https://pubmed.ncbi.nlm.nih.gov/20936400 11. 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Cheng RZ (2022) A Hallmark of Covid-19: Cytokine Storm/Oxidative Stress and its Integrative Mechanism. http://orthomolecular.org/resources/omns/v18n03.shtml Nutritional Medicine is Orthomolecular MedicineOrthomolecular medicine uses safe, effective nutritional therapy to fight illness. For more information: http://www.orthomolecular.org Find a DoctorTo locate an orthomolecular physician near you: http://orthomolecular.org/resources/omns/v06n09.shtml The peer-reviewed Orthomolecular Medicine News Service is a non-profit and non-commercial informational resource. Editorial Review Board:
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